SMURF: Unsupervised Flow Reconstruction from 4D Flow MRI

Summary

Joint inference of cardiac geometry and velocity fields from 4D flow MRI using a measurement model.

SMURF: Unsupervised Flow Reconstruction from 4D Flow MRI
SMURF: Unsupervised Flow Reconstruction from 4D Flow MRI

Overview

This project develops SMURF, a patient-specific framework that infers a probabilistic geometry field and a continuous velocity field directly from 4D flow MRI magnitude and phase-derived velocity data. The method formulates a coupled likelihood where shared class probabilities connect the geometry and velocity terms, so segmentation and velocity reconstruction are solved as one inference problem.

The fields are represented as coordinate-based models that can be evaluated on the acquisition grid or a finer query grid. Training uses subsampling over space and time to control compute cost and runs on a single GPU per case. Outputs include time-resolved segmentations, reconstructed velocity fields, and derived diagnostics such as conservation residuals computed from the reconstructed field.

Collaborators

External Collaborators:
  • Yue-Hin Loke
  • Pavlos Vlachos

PSL Partners

Eli Lilly
National Science Foundation
Children’s National Hospital

Scientific Machine Learning & AI for Engineering

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Ilias Bilionis